Modification of BTLA signaling motifs in TIL exhibits positive signals that mediate anti-tumor control
نویسندگان
چکیده
Background Our recent data have shown that a subset of CD8BTLA was the strongest predictive biomarker of response to adoptive T cell therapy using tumor-infiltrating lymphocytes. BTLA, B-and-T lymphocyte attenuator, is known as an inhibitory molecule in different immune cells. Its cytoplasmic region contains three motifs (Grb2, ITIM, and ITSM). ITIM and ITSM are inhibitory motifs that suppress T cell function upon ligation of the BTLA ligand, HVEM (Herpes virus entry mediator). However, the physiological function of Grb2 motif, known to interact with p85 PI3K, remains unclear. The aim of this study was to investigate the role of the Grb2 motif of BTLA in CD8 TIL and murine CD8 T cells.
منابع مشابه
Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter.
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